My research lies at the crossroad of molecular biology, biophysics and genetics – for want of better identified as ‘molecular cell biology’. I have been working on the architecture of eukaryotic chromatin focusing on molecular mechanisms that drive DNA recombination events. Since my PhD fellowship (and later as a faculty member of the Dept. of Biophysics and Cell Biology) I have addressed central problems of genome instability: key findings include (1) the discovery of persistent single-stranded DNA breaks in genomic regions that are prone to rearrangements in human malignancies, (2) the discovery of ribonucleoportein particles (RNA-DNA hybrids) in the proximity of these nicks. The latter finding was published in the Proceedings of the National Academy of Sciences of USA, which allowed me to establish fruitful collaborations involving leading experts in the field; e.g. Caroline Austin (Newcastle University, UK) who is an expert of topoisomerases and Alain Nicolas (Institut Curie, Paris) who then became my post-doc supervisor. A major strand of my work involves molecular knowledge on the developmentally (genetically) programmed DNA double-strand breaks (DSBs): I have been studying DSB formation during the differentiation program of meiosis in S cerevisiae. After 5 years of intense workload, together with the Nicolas group (Paris) and the group of Vincent Géli (Marseille) we found a cause-effect relationship between meiotic DSBs and the presence of an epigenetic tag, H3K4me3. This breakthrough – providing a definitive and unexpected explanation for the link between H3 lysine4 methylation and recombination – was published in Science (as joint-first author with Laurent Acquaviva, CRCM, Marseille) and it was highlighted in Nature Reviews Mol Cell Biol and in Molecular Cell. In 2015 I won the excellence grant of the Hungarian Academy of Sciences, called Momentum, and currently I am the group leader of the MTA-DE Momentum Genome Architecture and Recombination Research Group.
2008-2010 Post-doc (Alain Nicolas lab, Institut Curie, Paris, France)
2007 Ph.D. (Theoretical medicine, chromatin structure), University of Debrecen/ Hungary
Supervisor: Gábor Szabó (Dept. of Biophysics and Cell Biology)
2002 M.Sc. /molecular biology, biochemistry/ University of Debrecen/ Hungary
2015 – Group leader
The Hungarian Academy of Sciences
2015 – Senior lecturer
Department of Biochemistry and Molecular Biology, University of Debrecen, Hungary
2014 – Principal investigator (Genome architecture and recombination group)
Research Centre for Molecular Medicine, Debrecen, Hungary
2013 – Senior lecturer
Department of Biophysics and Cell Biology, University of Debrecen, Hungary
2007 – 2013 Assistant lecturer
Department of Biophysics and Cell Biology, University of Debrecen, Hungary
2017-2021 H2020-NKFIH GINOP2.3.2. In consortium with the Biological Research Centre of Szeged.
Role : PI.
2016 Institut d’études avancées (IMéRA), Marseille, France;
Role: visiting scientist at the Cancer Research Centre of Marseille (CRCM)
2016-2018 NKFIH-ERC_15 Research Grant / National Research, Development and Innovation Office;
2015-2020 Momentum Research Grant / The Hungarian Academy of Sciences;
Role: PI. Host: Research Centre for Molecular Medicine/ University of Debrecen
2014 – 2016 CRP-ICGEB International Research Grant / Trieste, Italy
2013 – 2014 Zoltán Magyary Postdoctoral Fellowship in the Convergence Regions / Hungary
2012 – 2016 EU-FP7 Marie Curie European Carrier Integration Grant (acronym: GLORI)
2011 – 2014 OTKA-PD Research Grant
2008 – 2010 EU-FP7 Marie Curie intra-European Fellowship
Host: Institut Curie, Paris, France (Recombination and Genome Instability Unit / PI: Alain Nicolas) Acronym: EMRES
2006 EMBO short-term Fellowship (3 Months) Host: Institut Curie, Paris, France (Recombination and Genome Instability Unit / PI: Alain Nicolas)
2016. Mini-conference on recombination and genome instability: from DNA breaks to crossover pattern formation (20-22. June 2016, The Cancer Research Centre of Marseille (CRCM), France)
2014 Danube Scientific Conferences on Epigenetics (2014 Nov 19-21st , Budapest, Hungary)
Speaker. Co-organizer with Bálint Bálint (Debrecen, Hungary), Tamás Arányi (Budapest, Hunagry), Wendy Bickmore (MRC, UK), Imre Boros (Szeged, Hungary), László Nagy ( Sanford Burnham, FL, US), Iannis Talianidis (Fleming Institute, Athens, Greece), László Tora (IGBMC, Strasbourg, France)
2013 23rd Wilhelm Bernhard Workshop on the Cell Nucleus (19-24th Aug 2013, Debrecen, Hungary). Speaker. Co-organizer with Gábor Szabó (Debrecen, Hungary).
2007- Biophysics for MD- molecular biologist- and pharmacologist students (atomic physics, radioactivity, X-ray/CT/PET/SPECT/MRI, ultrasound, lasers)
2007- Cell biology for MD- molecular biologist- and pharmacologist students (chromatin structure, cell cycle, meiosis)
2011- Modern biophysical methods (fluorescent techniques, FRET, FRAP, FCS)
2011- Selected topics in cell biology (title: “Recombination: break the genome to save it!”)
2011- Physics for physiotherapeutic students (electricity, nuclear physics)
2004- Cell biology, Biophysics, Physics, Biostatistics
2002- Cell biology, Biophysics
2007 – Faculty Committee Member / Dept. of Biophysics and Cell Biology/ University of Debrecen
2010– Faculty Coordinator of Cell Biological practices / Dept. of Biophysics and Cell Biology/ University of Debrecen
2010 – Ph.D. supervisor and scientific adviser / Doctoral School of Molecular Cell Biology and Immunbiology / Hungary
2011– Faculty Coordinator of the elective course “Modern biophysical methods” / Dept. of Biophysics and Cell Biology/ University of Debrecen
2014 – Faculty Coordinator / Students’ Research Society for Medical and Health Sciences/ University of Debrecen
2003 – Member / Hungarian Biophysical Society (MBFT)
2008 – Public Body Member / Hungarian Academy of Sciences
2014 – Member / Hungarian Biochemical Society (MBKE)
2014 – Member / Hungarian Genetic Society (MAGE)
2nd Danube Scientific Conferences on Epigenetics (5-8 October 2016, Budapest, Hungary). Invited speaker.
Mini-conference on recombination and genome stability: from DNA breaks to crossover pattern formation (22nd July 2016, Marseille, France). Organizer, speaker.
Institut d’études avancées (IMéRA), Aix Marseille University, France (03. March 2016). Invited speaker.
6th Central European Genome stability and Dynamics Meeting (9 – 10th October 2015), Biological Research Centre, Szeged, HUNGARY. Invited speaker.
XIV. “Genetikai Műhelyek Magyarországon” Minikonferencia. 2015. szeptember 4, SZBK, Szeged. Invited speaker.
24th Wilhelm Bernhard Workshop on the Cell Nucleus (17-22th August, Wien, Austria). Invited speaker.
EMBO Meiosis conference (30. August-04. September 2015, Oxford, UK). Poster presentation.
MBKE Epigenetikai Szakosztály alakuló ülés (2015.04.16., Budapest). Meghívott előadó.
Hungarian Molecular Life Sciences Conference (27-29th March 2015, Eger, Hungary). Invited speaker.
Danube Scientific Conferences on Epigenetics (Nov 20-22nd 2014, Budapest). Co-organizer, speaker.
5th Central European DNA Repair Meeting (Oct 10th 2014, Brno, Czech Republic. Invited speaker.
Annual meeting of the Hungarian Biochemical Society. Invited Speaker. (24-27th August, Debrecen, Hungary)
BRC Seminars (21st Jan. 2014, BRC Szeged, Hungary). Invited speaker.
4th Central European DNA Repair Meeting (Nov 8th 2013, Wien, Austria). Invited speaker.
4th Congress – Personalized Medicine in the mirror of interdisciplinarity (Sept. 6-7th 2013, Eger, Hungary) Invited speaker.
23rd Wilhelm Bernhard Workshop on the Cell Nucleus (19-24th August, Debrecen, Hungary) Co-organizer, speaker.
Hungarian Molecular Life Sciences Conference (Apr 5-7th 2013, Siófok, Hungary). Speaker.
Three dimensional genome organization seminar (Apr. 16th 2012, DKFZ, Heidelberg). Invited speaker.
1st Hungarian Epigenetic Conference – basic science and clinical applications (20-21st Sept. 2012, Budapest, Hungary). Invited speaker. Best short-talk price.
IX. Magyar Genetikai Kongresszus és XVI. Sejt- és Fejlődésbiológiai Napok (March 25-27th 2011, Siófok, Hungary). Invited speaker.